N-Cbz-D-leucine, Z-D-leucine
Z-D-leucine
CAS: 28862-79-5
Molecular Formula: C14H19NO4
N-Cbz-D-leucine, Z-D-leucine - Names and Identifiers
N-Cbz-D-leucine, Z-D-leucine - Physico-chemical Properties
| Molecular Formula | C14H19NO4 |
| Molar Mass | 265.3 |
| Density | 1.158±0.06 g/cm3(Predicted) |
| Boling Point | 442.8±38.0 °C(Predicted) |
| Appearance | clear liquid |
| Color | Colorless to Almost colorless |
| BRN | 2057659 |
| pKa | 4.00±0.21(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| MDL | MFCD00066068 |
N-Cbz-D-leucine, Z-D-leucine - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29242990 |
N-Cbz-D-leucine, Z-D-leucine - Reference Information
| Uses | N-benzyloxycarbonyl-D-leucine is an amino acid derivative that can be used as a biochemical reagent. |
| Overview | CBZ-D-leucine is also called N-benzyloxycarbonyl-D-leucine. CBZ-D-leucine is mainly used in polypeptide synthesis. Leucine has a wide range of uses and functions. In the prior art, Cbz is used as a protective group to protect D-leucine. CBZ-D-leucine is an important intermediate raw material for many kinds of medicine and biotechnology. |
| preparation | 25mmol of D-leucine is dissolved in 10ml of sodium hydroxide (NaOH) aqueous solution with a mass concentration of 10% at -5 ℃ to obtain the dissolved liquid. 35mmol (I .e. 4.5ml) of benzyl chloramate (Cbz-Cl) is added dropwise to the dissolved liquid at a rate of 1 drop/4 seconds while stirring for reaction, and drop the sodium hydroxide (NaOH) aqueous solution with a mass concentration of 10% to keep the PH at 8. After dropping, place it at 10°C, stir for 15 hours, use ninhydrin as the developer to develop color without purple, and then use 16ml/time Ether wash for 3 times, discard the ether, and get the aqueous phase. The aqueous phase is adjusted to 3 with concentrated hydrochloric acid with a mass concentration of 30%, and milky white solids appear, the liquid with milky white solid is extracted with 16ml/time of ethyl acetate for 3 times, merged, and the combined liquid is washed with 16ml/time of distilled water for 2 times, 16ml/time of saturated salt water for 1 time, and then dried with anhydrous magnesium sulfate for 10 hours, filtered, and the filtrate is concentrated under reduced pressure to obtain a light yellow oil. The mixed solvent prepared by ethyl acetate and petroleum ether with a volume ratio of 1:3 is used as the mobile phase, purification by chromatography column to obtain 4.0g CBZ-D-leucine, yield: 61.5%, anhydrous transparent oil. |
Last Update：2024-04-09 20:15:17
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Product Name: Z-D-Leu-OH Visit Supplier Webpage Request for quotationCAS: 28862-79-5
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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